HLA molecules (human leukocyte antigens) are highly polymorphic cellular surface proteins. HLA molecules are of central meaning to extraneous and endogenous antigens in the T-cellular immune response.
This explains the association between certain HLA characteristics with pathological immune reactions, such as autoimmune diseases and chronically persistent infections.
Proof of predisposed or even protective HLA characteristics ranks as an additional marker in the differential diagnosis of complex inflammatory diseases.
Tissue typing is of further clinical significance in HLA typing. In organ or stem cell transplants, the HLA characteristics of both the donor and recipient must match as far as possible to reduce the risk of rejection by the body to an absolute minimum.
We perform high and low resolution HLA typing in HLA class I (A, B, C) and class II (DR, DQ) using molecular-genetic methods (SSP-PCR and DNA sequencing).