Depending on composition, condition, position and size, due to abrasion and corrosion, metallic dentures emit metals into saliva and the surrounding tissue. In isolated cases, this may cause local or generalised gum inflammation. However, continuously increased metal concentrations in saliva do elevate the risk of a systemic metal burden of the entire organism.
Fig. 1 Due to abrasion and corrosion, metals are released. Possible consequences are sensitisations, as well as toxic effects. The extent can be determined in saliva using multi-element analysis.
In cases of existing hypersensitivity (detectable by LTT), even small concentration levels can cause type 4 immune reactions. The immune system’s continuous activation caused by persisting exposition can comprise all characteristics of chronic inflammation, such as amplification of local inflammatory processes, autoimmune disorders, and fatigue.
High metal concentrations in saliva or food can destroy gastric and intestinal mucosa and significantly increase the intestinal permeability. As a consequence, increased numbers of bacterial constituents originating from the intestinal flora migrate into the blood stream and cause systemic inflammations. Many metals can dose-dependently activate the innate immune system, as well as cause oxidative stress. Emerging free radicals attack cellular structures and cause damages to DNA, proteins and membranes.
Even low-level (sub-toxic) concentrations may be clinically relevant, since the combined burden (from food and drinking water as well!) may raise the toxic effect of a metal’s individual level to a higher power. Apart from their direct toxicity, metals such as cadmium and nickel do damage by suppressing essential minerals’ binding to metal-dependent enzymes
Multi-element analysis provides information about metal release from dentures.
The organism’s systemic burden differs from oral exposure, because
In order to detect the systemic burden originating from dentures, multi-element analysis from urine or EDTA blood is suitable – with the limitation that measured values may increase due to acute expositions from different sources, such as meals containing polluted fish.
Multi-element analysis «alloying metals« by means of ICPMS (see sample report below).
Fig. 2 Sample medical report multi-element analysis in chewing gum saliva
3-5 ml saliva, or 5 ml spontaneous urine, or 2 ml EDTA blood
Please obtain the costs for the analysis from the pdf-document.
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